Sale half-back Peter Stringer could miss three months of the Aviva Premiership campaign after tearing his biceps tendon.
Sale came back from trailing 31-17 to gain a late draw against Worcester in a nine-try thriller at Sixways.
Greig Laidlaw kicked 16 points as Gloucester secured their first victory of the season with a 26-13 triumph over Sale.
Sale Sharks boss Steve Diamond wants his players to establish some early-season momentum in the Aviva Premiership.
Harlequins back row Mat Luamanu has been banned for three weeks after appearing at an RFL disciplinary panel hearing.
Sale Sharks returned to winning ways with a 19-10 victory at home to Harlequins, who had Mat Luamanu sent off late on.
Newcastle survived a last-minute penalty kick at goal to beat Sale 19-17 in their opening Aviva Premiership game.
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Former player Cillian Willis is taking legal action against Sale Sharks, claiming he was allowed to carry on playing in a match despite suffering two head injuries.
Sale Sharks have signed forward Cameron Neild to a four-year contract extension.
Sale Sharks have announced back row TJ Ioane has signed a new three-year contract with the Aviva Premiership club.
Sale Sharks second row Bryn Evans has signed a new contract at the club.
Josh Beaumont has signed a new three-year contract with Sale Sharks and will also be club captain for the coming season.
Sale Sharks' Director of Rugby Steve Diamond is targeting a top-four finish in the Aviva Premiership next season.
The British and Irish Lions will be strong in New Zealand next year, with Eddie Jones' English stars leading the way, says Fran Cotton.
Edinburgh Rugby have signed Tonga back-row Viliami Fihaki on a two-year deal.