Australia cruised to victory in the deciding ODI with England at Old Trafford, winning by eight wickets after bowling the hosts out for 138 within 33 overs.
Aaron Finch (70no) and George Bailey (41no) saw their side home in just 24 overs after England had picked up the early wickets of Joe Burns and Steve Smith.
However, the damage was done in the first innings when Mitchell Marsh was the pick of the bowlers as he claimed 4-27, John Hastings was also impressive in taking 3-18 as Ben Stokes topped scored with 42 for England.
Having won the toss and elected to bat England got off to a nightmare start and found themselves 22-3 in the sixth over.
The in-form Jason Roy (4) was the first man to go, lbw to Mitchell Starc in the first over. Having already successfully reviewed an lbw decision earlier in the over, Roy mistakenly decided against going for another as Hawkeye showed the ball was sliding down leg.
He was joined back in the hutch shortly afterwards by opening partner Alex Hales (4), slashing at a ball wide outside off from Hastings and succeeding only in picking out Glenn Maxwell at backward point.
James Taylor (12) became Hastings' second victim, feathering a seaming delivery through to Matthew Wade behind the stumps.
A captain's innings was needed from Eoin Morgan but any chances of that were dashed when the skipper was hit flush on the helmet by a sharp bouncer from Starc.
He was forced to retire hurt and later being diagnosed with concussion, meaning the hosts were essentially four down and very much under the cosh.
Stokes and Jonny Bairstow went about leading the recovery and took England past 50. However, just as it appeared the pair were making headway, Bairstow fell.
The Yorkshireman was rapped on the pads by Marsh and despite a not out decision on the field, Australia went for the review and ball-tracking showed the ball was hitting and Bairstow (10) had to go.
Moeen Ali hit a beautiful cover drive for four first ball but it was a rare moment to savour for England as the all-rounder edged behind off Marsh have added just one further run.
David Willey came and went in the same over, trapped lbw second ball after an unsuccessful review.
Stokes remained and looked like England's only hope, batting aggressively as the wickets fell around him.
He signalled his intentions further as he powered Marsh back over his head for six to move on to 42 but the seamer had his revenge later in the over, pinning the Durham man in front for his fourth wicket.
That wicket left England seven down and still 15 shy of 100. Adil Rashid and Mark Wood decided to play their shots, the latter pulled for four through mid-wicket to bring up the century for England to ironic cheers.
He was gone soon after though, holing out to Ashton Agar in the deep to give Hastings his third wicket.
Rashid continued to bat sensibly, while looking to keep the scoreboard ticking along as best he could with ODI debutant Reece Topley doing his bit to support him.
The pair kept Australia waiting for their final wicket with Rashid starting to get going with a couple of boundaries, ending on 35 not out, before Agar had Topley (6) lbw to wrap up the innings.
After a quick turnaround, Australia's chase got off to an ominous start as Burns edged behind off the bowling of Willey without scoring.
Finch and Smith looked to keeping things ticking along at a leisurely pace before lunch but the captain snicked off to Wood in the last over before the interval to jut England a glimmer of hope.
However, Finch and Bailey upped the temp when play resumed with Rashid, in particular, being targeted for quick runs.
Finch moved past 50 with a sweetly-timed sweep off Moeen Ali and continued to play the shot with success as the finish line drew ever nearer.
Bailey hit the winning runs, edging wide of Bairstow and watching the ball run away to third man for four and condemning England to their first series defeat in any form of the game this summer.