Alexander Zverev recorded his first victory over troubled world No 1 Rafael Nadal as the German made a perfect start to his ATP Finals defence.
The Spaniard suffered an abdominal problem at the Paris Masters and it appeared on this showing that he has not fully recovered for the season-ending tournament in London.
He couldn't match the power and precision shown from Zverev, who dominated in every aspect to pull off somewhat of an upset win, 6-2 6-4.
Whether Nadal will be able to hold off Novak Djokovic for the year-end top spot will be the big story this week.
US Open champion Nadal had been unable to serve because of the injury and he was unsurprisingly tested in every service game until he succumbed under mounting pressure by the German, who broke through a couple of times to take the opening set.
Indoor hard courts have never been Nadal's favourite surface and injury has often got in the way of his participation at the ATP Finals.
The 2010 and 2013 runner-up here has withdrawn ahead of the tournament six times since he first qualified in 2005 and two years ago was only able to complete one match.
Zverev, who claimed the biggest title of his career here last year, continued where he had left off in the first set by outplaying his opponent in every department.
The 22-year-old moved 2-0 up, while 19-time Grand Slam champion Nadal was being forced to dig deep after an eight-minute service game just to hold serve in the fifth game. Zverev served out the contest to seal a convincing win after one hour and 24 minutes.
No 1 up for grabs...
With Nadal's loss, Djokovic now controls his own destiny for the year-end No 1 ranking. If Djokovic goes 5-0 at the ATP Finals, he will tie Pete Sampras' record with his sixth finish at No 1 in ATP Rankings.
Stats of the match
Rafael Nadal vs Alexander Zverev: Match Stats
Nadal
Match Stats
Zverev
5
Aces
11
0
Double Faults
2
62%
1st serve win percentage
88%
43%
2nd serve win percentage
47%
3/7
Net points won
6/8
0/0
Break points won
3/4
13
Winners
26
17
Unforced errors
20
45
Total points won
64
Zverev recorded his first victory over Nadal having lost all his previous five meetings.
Carrots and spinach for Sascha
It's great, everyone knows how much I struggled all season so to play here, after winning my biggest title last year, means everything. My fast serving? Carrots and spinach, whatever mum was giving me, is why I was doing this. Coming back here to practice last week was amazing, just being out here and
in this stadium is something I wanted to do this year again. It was a huge goal. There were not a lot of ups this season. So, I hope I can play my best tennis this week.
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Greek sixth seed Tsitsipas had not beaten Medvedev, this year's US Open runner-up, in five previous meetings with the Russian.
But the 21-year-old found London's O2 Arena to his liking as he battled to a 7-6 (7-5) 6-4 victory in a high-quality contest.
Russian Medvedev, 23, has won more matches than any other player this year, his total of 59 victories being five more than Novak Djokovic has managed.
But he could not manufacture a single break point against the dogged Tsitsipas, who secured the only break of the match at 5-4 in the second set before serving out the win.
Stats of the match
Daniil Medvedev vs Stefanos Tsitsipas: Match Stats
Medvedev
Match Stats
Tsitsipas
6
Aces
5
0
Double Faults
0
72%
1st serve win percentage
89%
54%
2nd serve win percentage
41%
5/11
Net points won
22/26
0/0
Break points won
1/4
24
Winners
26
16
Unforced errors
28
73
Total points won
77
Did you know...
18 of the last 19 singles matches at the ATP Finals have finished in straight sets [including both Monday's matches]
Tsitsipas: I had goosebumps
It was one of the toughest, most important victories of my career so far. I gave myself a big boost, I kept believing, kept fighting, believing in
myself, and that last game was one of the toughest. It's such a relief. It's not easy coming in knowing you lost five before, but I made a deal with myself to keep trying. I had great support, there are Greek flags everywhere, it feels like I'm playing in Athens. I had goosebumps.
Medvedev frustrated
He was better today, but I felt like I was missing some things. This frustrates me after. I do think it would frustrate me against any other opponent. I hate to lose against anybody. Of course I wanted to make it even more bigger head-to-head, but it's the way it is.
Who plays who next...
Zverev takes on Tsitsipas in the second round-robin matches on Wednesday, while the pressure is on Nadal when he faces Medvedev in a rematch of their US Open final marathon, which the Spaniard won.
Check our news, reports and reaction at the ATP Finals in London by following us on skysports.com/tennis, our app for mobile devices or our Twitter account @skysportstennis.