Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Juventus clinched a record sixth straight Serie A title with a 3-0 win over Crotone in the penultimate round on Sunday.
England goalkeeper Joe Hart had a game to forget as Torino were thrashed 5-0 by Napoli, while Roma beat Juventus.
Sulley Muntari is to be punished for walking off the pitch despite the Pescara player's claim he was racially abused during a Serie A game.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Juventus' Gonzalo Higuain failed to score on his long-awaited return to Napoli as the game ended 1-1, while Crotone beat Chievo.
Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.
Mauro Icardi and Ever Banega scored hat-tricks as Inter Milan thrashed Atalanta 7-1 in Serie A on Sunday.
Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Roma closed the gap on Serie A leaders Juventus to seven points with a 3-1 win away to Inter Milan at San Siro.
Gonzalo Higuain scored twice as Juventus preserved their seven-point lead in Serie A with a 2-0 victory at 10-man Cagliari.
Juan Cuadrado's thunderbolt gave Juventus 1-0 home win over Inter Milan on Sunday, as Sampdoria beat AC Milan and Lazio hit six.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as leaders with a 2-0 win over Sassuolo.
Paulo Dybala and Gonzalo Higuain scored as Serie A leaders Juventus beat fourth-placed Lazio 2-0 on Sunday.
Fiorentina put a dent in Juventus' title charge with a 2-1 win at the Stadio Artemio Franchi.
Serie A leaders Juventus returned from their winter break with a 3-0 dismantling of Bologna on Sunday night.
Roma bounced back from their Serie A defeat to Juventus at the weekend by coming from behind to beat Chievo 3-1.
A fine solo goal from Gonzalo Higuain stretched Juventus' lead at the top of Serie A to seven points following a 1-0 victory over Roma.
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