Tennessee kicker Stephen Gostkowski recovered from an evening of kicking misery to kick the winning field goal as the Titans beat the Denver Broncos 16-14.
Ben Roethlisberger returned to the starting line-up, and JuJu Smith-Schuster was back to form as Pittsburgh chalked up a 26-16 victory over the New York Giants.
An MRI confirmed that Indianapolis Colts running back Marlon Mack sustained a torn Achilles tendon and will miss the rest of the season.
The effects of the Dallas Cowboys' loss to the host Los Angeles Rams are likely to have lasting consequences as a result of injuries to several players.
Tom Brady and Bruce Arians were left frustrated by costly turnovers in the Buccaneers' defeat to the Saints.
Sky Sports' Neil Reynolds breaks down six storylines from Week One of the 2020 NFL season.
Drew Lock moves into the spotlight on Monday as the Denver Broncos unveil an explosive new offense in their Week One clash with the Tennessee Titans.
Russell Wilson and Aaron Rodgers threw for four TDs, while the Jaguars, Cardinals and Washington pulled off upset wins in Week One of the NFL.
Malcolm Brown rushed for two TDs as the Los Angeles Rams opened their new $5 billion stadium with a 20-17 victory over the Dallas Cowboys.
Tom Brady endured a difficult debut with the Tampa Bay Buccaneers as he was intercepted twice in a 34-23 loss to the New Orleans Saints.
Cam Newton threw for 155 yards and rushed for 76 yards and two touchdowns as he started his New England Patriots career with a 21-11 victory over the Miami Dolphins.