Courtney Lawes has withdrawn from England's Six Nations squad due to take on France, while Marcus Smith has been retained over George Ford in the 27-player group.
Rampant Bristol reeled off a third successive Premiership victory after crushing play-off hopefuls Northampton 62-8 at Ashton Gate.
Round-up of Saturday's Gallagher Premiership action as Saracens extended their lead at the top of the table.
Manu Tuilagi's hopes of representing England in this year's Six Nations were dealt a further blow after a red card.
Northampton and Saracens claim one-point victories over Leicester and Bristol respectively as Exeter battle past Gloucester in the Gallagher Premiership.
MPs have warned the financial situation of Premiership clubs is "clearly unsustainable" in a damning report on issues facing the game in England.
Munster held on to beat Northampton Saints 27-23 in a nail-biting second half in the European Cup, despite Jack O'Donoghue's early red card.
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