Duhan van der Merwe will have the chance to become Scotland's all-time record try-scorer after being restored to the side for the game against Uruguay.
Scotland powered past USA, helped with a Ewan Ashman hat-trick, with Duhan van der Merwe also equalling the Scottish try-scoring record in a 42-7 victory, in Washington
Scotland overwhelmed Canada, winning 73-12 at the start of their Americas tour.
Ireland clinched third place in the Women's Six Nations with a 15-12 victory over Scotland, which also secured their spot at next year's Rugby World Cup.
When are the Autumn Internationals? Who do England, Ireland, Scotland and Wales play and where? Full schedule and all you need to about this year's fixtures.
Scotland claimed victory in Italy for the first time this century to record their second win of the Women's Six Nations.
Two yellow cards saw Amy Cokayne sent off the field on her return from injury as England dominated Scotland in a 46-0 Six Nations win at The Hive Stadium in Edinburgh.
Relive commentary and analysis as England dominated Scotland with a 46-0 victory in Edinburgh in round three of the Women's Six Nations.