Juventus are interested in signing Isco and Tanguy Ndombele, according to Sky in Italy.
The Italian champions have already agreed a deal to bring Arsenal's Aaron Ramsey to Turin at the end of the season on a free transfer, but they are keen to further boost their midfield options.
Isco could be open to a move away from Real Madrid after finding first-team opportunities limited under new head coach Santiago Solari, starting just once in their last nine games.
Sky in Italy understands Juventus have held discussions with Isco's representatives over a potential switch to the Serie A. However, they are said to be facing competition from Manchester City.
Ndombele's performances for Lyon in Ligue 1 and the Champions League have caught Juventus' attention, with a meeting between his representatives and the club scheduled in the coming days.
Elsewhere, Juventus are lining up either Manchester United's Matteo Darmian or Chelsea's Emerson Palmieri as a replacement for left-back Leonardo Spinazzola, who looks set for a move to Bologna.