Harlequins defied their abysmal domestic form to stun La Rochelle 27-17 at Stade Marcel Deflandre and secure home advantage in the Champions Cup round of 16.
Munster bounced back from a disappointing defeat to Bath last week to comprehensively beat Gloucester 31-3 in the Champions Cup at Páirc Uí Chaoimh in Cork.
An astonishing start which saw Bath 28-0 ahead inside 19 minutes proved crucial as the Prem side saw off Munster 40-14 in their Champions Cup opener.
Northampton overcame the loss of injured captain George Furbank to post a statement 30-21 Investec Champions Cup win against the Bulls in Pretoria.
A round-up of Friday's action, as Bath suffered a setback in their Champions Cup opener and Gloucester came through a tough European Challenge Cup test against Edinburgh
Leinster rid the ghosts of their past vs Champions Cup holders La Rochelle, emphatically beating Ronan O'Gara's charges 40-13.
France centre Jonathan Danty will miss the rest of his country's Six Nations campaign including matches against Wales and England after being given a five-week ban.
Sale dropped into the Challenge Cup after being brushed aside by La Rochelle as the French giants kept alive their bid for a hat-trick of Champions Cup titles.
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