Defending champions Northampton suffered a shock defeat to Gloucester, while Bath returned to top of the Premiership and Sale beat Leicester.
Sale Sharks and England forward Jonny Hill has received a 10-week ban - with four weeks suspended - after accepting a charge that he abused a spectator.
Six-try Bath powered their way to a bonus-point victory over Sale Sharks to round off the first block of Gallagher Premiership matches in style.
Northampton bounced back from their derby disappointment in style as they trounced Sale while Newcastle earned their first Premiership victory in over a year.
Tom Roebuck scored twice as Sale cruised to a thumping 43-10 bonus-point win to condemn Newcastle to a 25th successive Premiership defeat.
England wing Tom Roebuck scored two tries as Sale secured a breathless 31-27 bonus-point win over Gloucester in the Gallagher Premiership.
England fly-half George Ford does not require surgery on his torn thigh muscle and could be fit for autumn internationals.
Leigh Halfpenny celebrated a first Gallagher Premiership try as Harlequins picked up a 28-14 bonus-point victory over Newcastle at Twickenham Stoop.