Go Ahead Eagles can only strive for a play-off place in their unlikely bid to avoid relegation after they were beaten 3-2 by Groningen.
Ajax thrashed NEC Nijmegen 5-1 to move level on points with Eredivisie leaders Feyenoord on Saturday.
Jens Toornstra scored a hat-trick as Eredivisie leaders Feyenoord thrashed struggling Go Ahead Eagles 8-0.
PSV Eindhoven moved up to second place in the Eredivisie after a 2-0 win at Sparta Rotterdam.
PSV Eindhoven beat Vitesse 1-0 to close the gap on second-placed Ajax to a point and move five behind leaders Feyenoord.
ADO Den Haag boosted their hopes of survival in the Eredivisie with a 1-0 home victory against NEC on Saturday.
Mathias Pogba struck the game's only goal as Sparta Rotterdam became the first team this year to beat Feyenoord in the Eredivisie.
Feyenoord scored late to beat PSV Eindhoven 2-1 and maintain their five-point lead at the top of the Eredivisie.
Feyenoord won their eighth Eredivisie game in a row as they beat FC Groningen 2-0 on Saturday to extend their lead at the top to eight points.
Title-chasing PSV Eindhoven triumphed 4-2 at AZ Alkmaar on Saturday, while Go Ahead Eagles and Heracles also won.
Davy Propper netted a late goal as PSV Eindhoven secured a 2-1 win at Heracles Almelo in the Eredivisie on Saturday.
FC Twente returned to winning ways after successive defeats with a 1-0 win in the Eredivisie over Heracles on Friday.
PSV Eindhoven moved level on points with second-placed Ajax as they beat Excelsior 2-0 at Philips Stadion.
A goal late in each half steered Heracles Almelo to three points as they beat NEC Nijmegen 2-0 at the Polman Stadion.
PSV Eindhoven remain third after only drawing 0-0 at Willem II on Saturday, while Excelsior, Heracles and Groningen all won.
Go Ahead Eagles ended Feyenoord's 23-game unbeaten streak in the Eredivisie after a famous 1-0 victory at De Adelaarshorst.
Hakim Ziyech's strike was enough as Ajax edged Excelsior with a 1-0 win to keep the pressure on Eredivisie leaders Feyenoord.
Feyenoord dropped points in the Eredivisie for the first time this season after a 1-1 draw with rivals Ajax.
Feyenoord maintained their winning start to the Eredivisie season at Willem II, while there was also a win for Ajax.
Davinson Sanchez and Kasper Dolberg both scored twice as Ajax beat Zwolle 5-1 while PSV won at Excelsior.