Caretaker boss Tony Adams saw his Granada side relegated from La Liga after suffering a 2-1 defeat at Real Sociedad.
Osasuna's relegation was confirmed after Leganes thrashed Las Palmas 3-0 on Wednesday.
Real Madrid will look to bounce back from their Clasico heartache but face a tricky task in doing so as they travel to Deportivo.
Willian Jose headed the winner as Real Sociedad boosted their Europa League hopes with a 1-0 success over Deportivo La Coruna.
Lionel Messi scored twice to help a tired Barcelona see off Real Sociedad 3-2 at the Nou Camp and close the gap on Real Madrid to three points.
Recap the action from the Nou Camp as Barcelona beat Real Sociedad 3-2 in La Liga.
Barcelona face another huge test of their character as they look to keep their La Liga title hopes alive in front of the Sky cameras.
Diego Simeone will stay with Atletico Madrid, says Guillem Balague in his weekly Q&A and chats Tony Adams, David de Gea and Toni Kroos.
Real Sociedad remained on course for European qualification after seeing off struggling Sporting Gijon 3-1 on Monday.
A Filipe Luis goal kept Atletico Madrid's winning run going as they beat Real Sociedad 1-0.
Atletico Madrid won 2-0 at Malaga on Saturday to climb to third, as Eibar and Athletic Bilbao also claimed away victories.
Brazilian forward Deyverson netted the winner as Alaves beat Basque rivals Real Sociedad 1-0 at Mendizorroza.
Who would make your La Liga best XI if you could only pick one player per team? Check out WhoScored.com's verdict.
Villarreal closed the gap back on the top four in La Liga with a 1-0 win at Celta Vigo on Sunday.
Barcelona, Real Madrid and Sevilla will be looking to avoid any slip-ups in the La Liga title race this weekend.
Jon Driscoll and Terry Gibson discuss Barcelona's defeat to Deportivo and the goalscoring exploits of Sergio Ramos.
Xabi Prieto scored twice as Real Sociedad moved up to fourth in La Liga with a thrilling 3-2 victory at Real Betis on Friday.
Watch Aissa Mandi's brilliant goal for Real Betis during their 3-2 home defeat to Real Sociedad on Friday night.
Real Sociedad head coach Eusebio Sacristan has ruled himself out of the running to replace Luis Enrique as Barcelona boss.
Eliaquim Mangala scored a rare goal as Valencia beat Leganes 1-0 in La Liga on Tuesday night.