Noah Caluori scored four tries as Saracens overwhelmed Newcastle 73-14 at StoneX Stadium.
Former England captain Jamie George will retire from rugby in 2027 after signing a new one-year contract at Saracens.
Harlequins defied their abysmal domestic form to stun La Rochelle 27-17 at Stade Marcel Deflandre and secure home advantage in the Champions Cup round of 16.
Northampton Saints were brought back down to earth after they suffered a 50-28 loss away to Champions Cup holders Bordeaux in a repeat of last season's final.
Adam Radwan scored two tries as Leicester kept in contention for a play-off spot with an impressive 36-28 win over Saracens.
Northampton stunned the Prem Rugby champions Bath with a devastating display of running rugby featuring a hat-trick of tries by freewheeling England back Tommy Freeman.
Munster bounced back from a disappointing defeat to Bath last week to comprehensively beat Gloucester 31-3 in the Champions Cup at Páirc Uí Chaoimh in Cork.
An astonishing start which saw Bath 28-0 ahead inside 19 minutes proved crucial as the Prem side saw off Munster 40-14 in their Champions Cup opener.
Bath snatched a 36-29 victory over Saracens that propelled them two points clear at top of the Gallagher Prem.
Tommy Freeman ran in four tries as Northampton Saints fought back to defeat Saracens 43-31 in Gallagher Prem clash.
On Saturday, a 19-year-old by the name of Noah Caluori stunned the rugby world by remarkably scoring five tries for Saracens vs Sale Sharks on his first Prem start.
England's Steve Borthwick says Owen Farrell is concentrating on playing for Saracens in the Prem for now, but adds he is watching all eligible English players.
Billy Searle's penalty with the final kick of the game secured Leicester a dramatic 22-20 victory over Gallagher Prem champions Bath.
Marcus Smith's return inspired Harlequins to their first win of the Prem season as Saracens saw their perfect start come to an end with a 20-14 loss at The Stoop.
Leicester staged an incredible fightback to beat Harlequins, whilst Exeter beat Newcastle, and Saracens took control of Bristol.
Owen Farrell has not ruled out a return to Test rugby with England but told Sky Sports he has to find form with Saracens at club level first.
England's Maro Itoje and Ireland's Tadhg Beirne have been selected as the starting Lions lock partnership for Friday's clash vs Argentina, live on Sky Sports.
Owen Farrell remains a master of composure capable of thriving in the Test match arena, according to Ronan O'Gara.
Owen Farrell will depart Racing 92 a year before the end of his contract in order to return to Saracens immediately.
Maro Itoje says being the first black captain of the Lions shows growth in the sport but the most important thing is a series win in Australia
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