PSV Eindhoven surrendered their 100 per cent record in disappointing fashion after being held to a 0-0 draw at home to Groningen.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Newcastle United goalkeeper Tim Krul has joined Ajax on loan until the end of the season.
Barcelona have completed the signing of Ajax goalkeeper Jasper Cillessen.
Thorgan Hazard and Raffael both scored hat-tricks as Borussia Monchengladbach eased into the Champions League group stage.
Newcastle goalkeeper Tim Krul is set to join Ajax on loan for the rest of the season, according to Sky sources.
Arsenal may be entertaining on the pitch, but they lack a key player with "personality", according to Patrick Vieira.
Barcelona have agreed a deal with Ajax to sign their goalkeeper Jasper Cillessen, according to Sky sources.
Defending champions PSV Eindhoven defeated PEC Zwolle 4-0 to secure top spot in the Eredivisie.
Borussia Monchengladbach beat Young Boys 3-1 in the first leg of their Champions League qualifier while Ajax were held at home.
Ajax were held to a draw by Roda JC in a four-goal thriller on Saturday, while Vitesse lost at home to ADO Den Haag.
Ajax have taken Bertrand Traore on a season-long loan from Chelsea with the 20-year-old also handed a new three-year contract.
Eljero Elia's hat-trick helped Feyenoord win 5-0 at FC Groningen on the opening weekend of the Eredivisie.
Radamel Falcao scored before coming off injured as Monaco beat Fenerbahce in Champions League qualifying, while Ajax are also through.
Napoli have acted swiftly to replace Gonzalo Higuain by completing the signing of Ajax forward Arkadiusz Milik.
Four-time European champions Ajax laboured to a 1-1 draw to PAOK in their Champions League third qualifying round tie.
Swansea are expected to sign Dutch duo Leroy Fer and Mike van der Hoorn from QPR and Ajax respectively.
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Clarence Seedorf has been appointed as the new head coach of Chinese second division club Shenzhen FC.
Middlesbrough head coach Aitor Karanka is closing in on his first summer signing, Ajax winger Viktor Fischer.