Billy Searle's penalty with the final kick of the game secured Leicester a dramatic 22-20 victory over Gallagher Prem champions Bath.
Gloucester slipped to a fourth successive Prem defeat of the season as west country rivals Bristol toppled them 49-34 at Kingsholm.
Marcus Smith's return inspired Harlequins to their first win of the Prem season as Saracens saw their perfect start come to an end with a 20-14 loss at The Stoop.
Finn Russell led Bath to a bonus-point 38-17 victory over Gloucester on his return to the team.
Playing rugby has no causal link to motor neurone disease, according to an expert in the incurable muscle-wasting condition.
Newcastle Red Bulls have parted company with director of rugby Steve Diamond after just one match of the new Prem season.
Debutant Nathan Jibulu scored a second-half try as Sale beat Gloucester 27-10 to claim a bonus-point win on the opening night of the Gallagher Prem season.
Owen Farrell has not ruled out a return to Test rugby with England but told Sky Sports he has to find form with Saracens at club level first.
Christian Wade has switched rugby codes again after leaving league's Wigan Warriors to join union outfit Newcastle Red Bulls from December.
The Bristol Bears have confirmed the signing of "'world class" Louis Rees-Zammit, who returns to rugby union for the new season after his stint in the NFL.
Former Wales winger Louis Rees-Zammit says he's had "a lot of interest" and hopes to find a new club "next week" after leaving the NFL and returning to rugby.
Owen Farrell will depart Racing 92 a year before the end of his contract in order to return to Saracens immediately.
Bath clinched their first Premiership title for 29 years dating back to 1996 after holding off a late Leicester Tigers fightback to win 23-21 at Twickenham.
Outgoing Leicester Tigers head coach Michael Cheika said Premiership final referee Karl Dickson "gave us nothing," labelling the Dan Cole sin-binning "embarrassing."
Recap live commentary from Saturday's Premiership final as Bath held on to beat Leicester Tigers 23-21 at Allianz Stadium Twickenham.
The end of treble-chasing Bath's 29-year wait for the title, or a fairytale Leicester farewell for Dan Cole, Ben Youngs and co?
Adam Radwan scored two tries as Leicester set up a Gallagher Premiership final against Bath by edging Sale 21-16.
Leicester, Sale and Bristol earned the wins they needed to wrap up Premiership play-off spots as Gloucester and Saracens missed out on the top four.
Owen Farrell could return to Saracens next season as injury cover - if he accepts a salary less than what he is currently on at Racing 92.
Lawrence Dallaglio chats to Sky Sports about his career and 1997, 2001 and 2005 British & Irish Lions tour memories as part of our Lions Recollections digital series.