Marcus Smith has signed a new long-term contract that will keep him at Harlequins until at least 2028.
Defending champions Northampton suffered a shock defeat to Gloucester, while Bath returned to top of the Premiership and Sale beat Leicester.
Harlequins said goodbye to Joe Marler and their reputation as one of the Gallagher Premiership's meanest defences as irresistible Bristol stormed The Stoop 48-24.
Sale Sharks and England forward Jonny Hill has received a 10-week ban - with four weeks suspended - after accepting a charge that he abused a spectator.
Henry Slade proved his fitness ahead of England's Autumn Nations Series opener but could not prevent Exeter from suffering defeat by Harlequins.
Six-try Bath powered their way to a bonus-point victory over Sale Sharks to round off the first block of Gallagher Premiership matches in style.
Bristol regained top spot in the Gallagher Premiership as centre Kalaveti Ravouvou scored two tries to underpin a 31-23 victory over champions Northampton at Ashton Gate.
Alex Lozowski booted a penalty with the game's final kick as Saracens claimed a thrilling 37-35 Gallagher Premiership victory over Bristol at Ashton Gate.
Northampton bounced back from their derby disappointment in style as they trounced Sale while Newcastle earned their first Premiership victory in over a year.
Tom Roebuck scored twice as Sale cruised to a thumping 43-10 bonus-point win to condemn Newcastle to a 25th successive Premiership defeat.
England head into the 2024 Six Nations with head coach Steve Borthwick seeking big improvements on the last three years, but after a lot of disruption.
Gloucester broke their miserable run of nine consecutive Gallagher Premiership defeats with a morale-boosting 32-20 win over Sale at Kingsholm.
All of the details from Saturday's three Gallagher Premiership matches as Northampton, Bristol and Saracens all won.
Jarrod Evans' missed conversion with the last kick of the game saw Harlequins edged out 20-19 by Leicester on Friday.
Racing 92 have confirmed the signing of Owen Farrell on a two-year contract.
Louis Rees-Zammit speaks to Sky Sports about his NFL ambitions after leaving behind a promising rugby union career.
Steve Borthwick tells Sky Sports captain Jamie George signing the first RFU hybrid-contract is 'a big statement' as far as England retaining their best players.
Stuart Lancaster has confirmed Racing 92 are interested in recruiting Owen Farrell from Saracens but no deal is yet done.
Full-back Tom de Glanville scored two tries as Gallagher Premiership title contenders Bath returned to winning ways.
Saracens boss Mark McCall says "everybody would want" Owen Farrell in their side, with Racing 92 believed to be in talks to sign the England captain.