Dejan Lovren has completed his move from Liverpool to Zenit Saint Petersburg for a fee of around £11m.
Liverpool revealed the news on Twitter and said: "We can confirm Lovren has joined Zenit Saint Petersburg on a permanent transfer.
"Everyone at the Reds would like to thank Dejan for his brilliant contribution over the years and wish him all the very best in his new challenge."
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Liverpool signed Lovren from Southampton for £20m in July 2014 and he has since helped the club win both the Champions League and Premier League under Jurgen Klopp.
However, the 31-year-old has found his first-team opportunities limited in recent seasons, with Virgil van Dijk, Joe Gomez and Joel Matip largely preferred in central defence. This season he was limited to 15 appearances in all competitions.
Reds manager Jurgen Klopp paid tribute to Lovren and acknowledged how important the player had been to him during his early days at the club.
"Another Liverpool legend who leaves the club, because he was absolutely a very, very important part of this team from the first day since I was in," Klopp said.
"When he was fit, he was very, very, very often in the team. A great player and a great person. Really good, in the air a machine, and I really liked working together with him.
"It will be interesting to follow Zenit St. Petersburg now. I wish him the best of luck."
In addition to Van Dijk, Matip and Gomez, Liverpool currently have Dutch 18-year-olds Ki-Jana Hoever and Sepp van den Berg as options in the position.
The summer transfer window will run for 10 weeks from July 27 and close at 11pm on October 5.
A domestic-only window for trades between the Premier League and EFL then runs from October 5 and closes on Friday October 16 at 5pm. Follow all the news and analysis on Sky Sports News and across Sky Sports' digital platforms, including with our dedicated Transfer Centre blog.