Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.
Mauro Icardi and Ever Banega scored hat-tricks as Inter Milan thrashed Atalanta 7-1 in Serie A on Sunday.
Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Roma closed the gap on Serie A leaders Juventus to seven points with a 3-1 win away to Inter Milan at San Siro.
Gonzalo Higuain scored twice as Juventus preserved their seven-point lead in Serie A with a 2-0 victory at 10-man Cagliari.
Juan Cuadrado's thunderbolt gave Juventus 1-0 home win over Inter Milan on Sunday, as Sampdoria beat AC Milan and Lazio hit six.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as leaders with a 2-0 win over Sassuolo.
Paulo Dybala and Gonzalo Higuain scored as Serie A leaders Juventus beat fourth-placed Lazio 2-0 on Sunday.
Roma bounced back from their Serie A defeat to Juventus at the weekend by coming from behind to beat Chievo 3-1.
A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Roma were unable to keep pace with Serie A leaders Juventus after they were held to a goalless draw at struggling Empoli.
Joe Hart was at fault for Mauro Icardi's first goal as Inter Milan beat Torino 2-1 in Serie A on Wednesday.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.
Inter Milan were held to a 1-1 draw at home by Bologna in Serie A on Sunday after a fine volley from Ivan Perisic.
Mauro Icardi inspired a superb comeback win for Inter as they beat Juventus 2-1 on Sunday, while Roma lost at Fiorentina.
Gonzalo Higuain starred for Juventus with two goals as they beat Sassuolo 3-1 in Serie A on Saturday, as Napoli won 3-0 at Palermo.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Inter Milan suffered a surprise 2-0 defeat to Chievo on the opening weekend of Serie A while Napoli also struggled.
Francesco Totti made his 600th Serie A appearance as Roma moved up to second spot with a 3-0 win over Chievo.