Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
All the latest transfer rumours from the European papers, including reports Arsenal want Barcelona attacker Arda Turan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Edin Dzeko set a new club record for Roma with both goals in a 2-0 victory over Empoli at the Stadio Olympico, as Lazio beat Sassuolo.
Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.
Mauro Icardi and Ever Banega scored hat-tricks as Inter Milan thrashed Atalanta 7-1 in Serie A on Sunday.
Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Roma closed the gap on Serie A leaders Juventus to seven points with a 3-1 win away to Inter Milan at San Siro.
Gonzalo Higuain scored twice as Juventus preserved their seven-point lead in Serie A with a 2-0 victory at 10-man Cagliari.
Juan Cuadrado's thunderbolt gave Juventus 1-0 home win over Inter Milan on Sunday, as Sampdoria beat AC Milan and Lazio hit six.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as leaders with a 2-0 win over Sassuolo.
Paulo Dybala and Gonzalo Higuain scored as Serie A leaders Juventus beat fourth-placed Lazio 2-0 on Sunday.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Roma bounced back from their Serie A defeat to Juventus at the weekend by coming from behind to beat Chievo 3-1.
A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Roma were unable to keep pace with Serie A leaders Juventus after they were held to a goalless draw at struggling Empoli.
Joe Hart was at fault for Mauro Icardi's first goal as Inter Milan beat Torino 2-1 in Serie A on Wednesday.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.