Inter Milan were held to a 1-1 draw at home by Bologna in Serie A on Sunday after a fine volley from Ivan Perisic.
Mauro Icardi inspired a superb comeback win for Inter as they beat Juventus 2-1 on Sunday, while Roma lost at Fiorentina.
Gonzalo Higuain starred for Juventus with two goals as they beat Sassuolo 3-1 in Serie A on Saturday, as Napoli won 3-0 at Palermo.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Inter Milan suffered a surprise 2-0 defeat to Chievo on the opening weekend of Serie A while Napoli also struggled.
Francesco Totti made his 600th Serie A appearance as Roma moved up to second spot with a 3-0 win over Chievo.
Mario Balotelli faces an uncertain future after Serie A side Sassuolo turned down the chance to sign him.
Juventus celebrated winning the Serie A title for the fifth year in a row by beating relegation-threatened Carpi 2-0.
Paulo Dybala scored twice as Juventus thrashed Lazio 3-0 to take what could prove to be a decisive lead in Serie A.
Juventus moved a step closer to a fifth straight Serie A title after pulling nine points clear with a 4-0 win over Palermo.
Paul Pogba sustained Juventus' march towards a fifth straight Serie A title by completing a 2-1 comeback victory over AC Milan.
Juventus moved six points clear at the top of Serie A with a 1-0 win over Empoli on Saturday.
Goalkeeper Gianluigi Buffon added another record to his decorated career during Juventus' 4-1 win over local rivals Torino.
Paulo Dybala's superb first-half strike sent Juventus six points clear at the top of Serie A after a 1-0 home win over Sassuolo.
Roma routed Palermo without Francesco Totti on Sunday, while Fiorentina kept pace in the Serie A title race.
Juventus moved above Napoli at the top of Serie A after Simone Zaza's late goal secured a 1-0 win over the Azzurri.
Gonzalo Higuain scored a late penalty to give Napoli a 1-0 victory over Carpi on Sunday and keep them top of Serie A.
Crystal Palace are bottom of the Europe-wide form table - and only one Premier League team makes the top 10.
Stephan El Shaarawy scored on his Roma debut as the Giallorossi recorded a 3-1 victory over Serie A strugglers Frosinone.
Domenico Berardi converted a penalty in injury time on Sunday to give Sassuolo a shock 1-0 win away at Inter Milan.