Ousmane Dembele and Lionel Messi fired Barcelona to a confidence-boosting 2-0 win at in-form Sevilla on Saturday to keep the pressure on Atletico Madrid.
Manchester City sent out a message to their Champions League rivals with a dominant 2-0 victory over Borussia Monchengladbach.
Team news and stats ahead of Monchengladbach vs Man City in the Champions League last 16 on Wednesday; kick-off 8pm.
Borussia Monchengladbach head coach Marco Rose will join Borussia Dortmund at the end of the season.
The Champions League last-16 action continues on Wednesday - get the lowdown as Man City and Real Madrid gear up for their first legs.
Manchester City will play the first leg of their Champions League last-16 tie against Borussia Monchengladbach at the Puskas Arena in Budapest.
Real Madrid suffered a huge dent to their La Liga title ambitions following a surprise 2-1 defeat by Levante.
Borussia Monchengladbach broke their jinx against neighbours Borussia Dortmund with a 4-2 home win that sent them up to fourth place in the Bundesliga.
Bayer Leverkusen secured a 2-1 win over Borussia Dortmund, while Sevilla moved up to fourth in La Liga.
Borussia Monchengladbach battled back from two goals down to stun champions Bayern Munich 3-2 on Friday, with a double from Jonas Hofmann.
Real Madrid moved top of La Liga after a 2-0 home win over Celta Vigo with Lucas Vazquez and Marco Asensio on the scoresheet.
Borussia Monchengladbach forward Marcus Thuram has been banned for five games after he spat in the face of Hoffenheim defender Stefan Posch.
Borussia Monchengladbach forward Marcus Thuram has apologised for spitting in an opponent's face during a game as he faces a lengthy ban.
Chelsea will face Atletico Madrid in the Champions League last 16, while Liverpool play last season's semi-finalists RB Leipzig.
Karim Benzema scored twice as Real Madrid overcame Borussia Monchengladbach 2-0 at the Alfredo Di Stefano Stadium to seal a Champions League last-16 spot.
Barcelona's dismal start to the La Liga season continued as a second-half winner from substitute Alvaro Negredo handed Cadiz another major top-flight scalp.
The Champions League group phase is nearing its climax, but there are still a number of issues to be decided this week, including the fate of Real Madrid.
A costly mistake from goalkeeper Thibaut Courtois helped Alaves secure a 2-1 La Liga victory over Real Madrid at the Alfredo Di Stefano stadium.
Robert Lewandowski continued his hot goal-scoring streak with a hat-trick in Bayern Munich's 5-0 thumping of Eintracht Frankfurt.
Sergio Ramos' late penalty helped secure Real Madrid a 3-2 victory at Real Betis, who finished the La Liga match with 10 men, plus all the latest from around Europe.
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