Test centurion Courtney Lawes has revealed he will retire from England duty following the Rugby World Cup.
Bath maintained their winning start in the Gallagher Premiership with a 25-16 triumph over defending champions Saracens, while Sale and Bristol were also victorious.
Players from Northampton and Leicester, including Courtney Lawes and Ben Youngs, will join England's World Cup training squad in Brighton.
Saracens surged into the Premiership final but their 38-15 victory over Northampton was tinged with controversy.
Northampton are one win away from securing automatic promotion to Sky Bet League One after beating Harrogate 3-1 at home.
Northampton remain in the hunt for a Gallagher Premiership semi-final place after easing past rock-bottom Newcastle Falcons 66-5.
Round-up of Saturday's Gallagher Premiership action as Northampton Saints beat 14-man Saracens and Harlequins defeated Newcastle Falcons.
A round-up of Sunday's Gallagher Premiership action as Saracens beat Harlequins and Leicester Tigers beat Bristol Bears, while London Irish beat Northampton Saints.
Courtney Lawes has withdrawn from England's Six Nations squad due to take on France, while Marcus Smith has been retained over George Ford in the 27-player group.
Rampant Bristol reeled off a third successive Premiership victory after crushing play-off hopefuls Northampton 62-8 at Ashton Gate.
Round-up of Saturday's Gallagher Premiership action as Saracens extended their lead at the top of the table.
Manu Tuilagi's hopes of representing England in this year's Six Nations were dealt a further blow after a red card.
Northampton and Saracens claim one-point victories over Leicester and Bristol respectively as Exeter battle past Gloucester in the Gallagher Premiership.
MPs have warned the financial situation of Premiership clubs is "clearly unsustainable" in a damning report on issues facing the game in England.
Munster held on to beat Northampton Saints 27-23 in a nail-biting second half in the European Cup, despite Jack O'Donoghue's early red card.
A round-up of Saturday's Gallagher Premiership action as Newcastle battered Leicester, while Exeter proved too strong for Northampton.
Northampton emphatically ended a run of four successive defeats in the Gallagher Premiership and Champions Cup by beating Harlequins 46-17 at Franklin's Gardens.
A Gavin Coombes double, and an immense second-half defensive performance, saw Munster secure a fiery 17-6 win over Northampton Saints.
Saracens produced a comeback 45-39 victory over Northampton to maintain their unbeaten Gallagher Premiership record at the StoneX Stadium.
Recap Saturday's Premiership action as Harlequins beat London Irish late in a fiery derby, while Northampton were too strong for Bristol.
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