Exeter's impressive run at Sandy Park continued with a 10th consecutive victory in all competitions as they beat Sale 24-22 to maintain their hopes of a play-off spot.
Manu Tuilagi's hopes of representing England in this year's Six Nations were dealt a further blow after a red card.
Arron Reed scored a last-minute try to give Sale a dramatic win over Bath in the Gallagher Premiership.
MPs have warned the financial situation of Premiership clubs is "clearly unsustainable" in a damning report on issues facing the game in England.
Leinster and Toulouse book Champions Cup last-16 places after wins at Gloucester and Sale
Owen Farrell will be available for England's Six Nations opener against Scotland with his four-match ban for a high tackle set to be reduced to three weeks.
A round-up of Sunday's Gallagher Premiership action as Sale Sharks proved too strong for Harlequins, with London Irish cruising past Bristol Bears....
Impressive Sale beat Leicester 40-5 as interim head coach Richard Wigglesworth suffered his first defeat since taking over from Steve Borthwick.
Newly appointed England coach Steve Borthwick watched on as Gallagher Premiership leaders Saracens lost their unbeaten record in a feisty 29-20 defeat at London Irish.
Harlequins avenged their harrowing home defeat by Racing 92 two years ago by dispatching the French heavyweights 14-10 in their Heineken Champions Cup clash.
Sale began their Heineken Champions Cup campaign with an emphatic win over Ulster, while Saracens turned things around to beat Edinburgh.
Saracens maintained the unbeaten start to their Gallagher Premiership campaign with a convincing victory over Bristol.
England flanker Courtney Lawes' participation in this season's Six Nations is in doubt after he limped off during Northampton's defeat to La Rochelle.
Alex Goode produced a virtuoso display to celebrate his entry into Saracens' history books, while Theo McFarland stood out in win vs Sale.
Owen Farrell and Jonny May have withdrawn injured from England's training camp squad ahead of the Autumn Nations Series.
Marcus Smith proved the difference for Harlequins as they put an end to Sale's unbeaten start in the Premiership this season.
Five-try Sale Sharks eased to a 37-14 Gallagher Premiership victory over London Irish at the AJ Bell Stadium on Friday.
Premiership Rugby wants to introduce an independent regulator to oversee clubs' finances.
Recap Saturday's Premiership action as Sale won at champions Leicester, while Bath lost again in their derby vs Gloucester.
Recap Saturday's Premiership action as Saracens thumped defending champions Leicester, while London Irish and Sale beat Bath and Exeter respectively.
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