Getafe moved a step closer to earning Champions League football for the first time in their history after beating Athletic Bilbao 1-0 on Sunday.
Zinedine Zidane suffered his first defeat since retaking the reins at Real Madrid as Valencia ran out 2-1 winners at the Mestalla.
Karim Benzema scored a last-gasp winner to secure victory and spare Real Madrid's blushes against La Liga bottom club Huesca.
Adnan Januzaj scored for Real Sociedad but the San Sebastian side were held to a late 1-1 draw by Levante.
Wissam Ben Yedder bagged a 13-minute hat-trick in the second half as Sevilla cruised to a 5-2 triumph over Real Sociedad in La Liga.
Barcelona marked the signing of a new contract for coach Ernesto Valverde with a 1-0 win over relegation-battlers Real Valladolid on Saturday night.
Lionel Messi's two goals were not enough for Barcelona to salvage a win as they were held to a 2-2 draw at home to Valencia.
Atletico Madrid cut the gap to La Liga leaders Barcelona to two points as they beat Getafe 2-0 at the Wanda Metropolitano.
Barcelona once again moved five points clear of title challengers Atletico Madrid after a hard-fought 3-1 victory over Leganes.
Barcelona beat Levante to reach the Copa del Rey quarter-finals, but could yet be thrown out of the competition.
Antoine Griezmann ensured that Atletico Madrid kept the pressure on Barcelona by scoring the only goal in a 1-0 win over Levante in La Liga on Sunday.
Barcelona suffered a shock 2-1 defeat in the first leg of their Copa del Rey last-16 tie at Levante on Thursday.
A late header from Wissam Ben Yedder ensured 10-man Sevilla escaped with a point at Leganes in La Liga on Sunday.
Lionel Messi scored yet another hat-trick as Barcelona cemented their place at the top of La Liga at Levante.
Levante moved back into sixth after snatching a last-gasp 4-4 draw in a dramatic encounter at Eibar.
Eibar were the first top-tier club to go out of this season's Copa Del Rey after a 4-2 aggregate defeat to Sporting Gijon.
Santi Mina scored twice as Valencia continued their recent upturn in form with a 3-0 victory over Rayo Vallecano at the Mestalla.
Alaves missed the chance to go second in La Liga after conceding an injury-time goal in a fiery 2-1 defeat to Basque rivals Eibar.
Real Madrid set an unwanted record during a surprise 2-1 home defeat to Levante.
Eibar ran out 3-2 winners at Girona in La Liga on Saturday, where there was an action-packed end to the first half.
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