Bristol defied a second-half onslaught from Harlequins to claim a 15-12 win at the Stoop that lifts them off the foot of the Premiership.
Harlequins avenged their harrowing home defeat by Racing 92 two years ago by dispatching the French heavyweights 14-10 in their Heineken Champions Cup clash.
Harlequins fell to defeat at South African side Sharks in their opening Heineken Champions Cup game as Leinster and Gloucester started with victories.
Harlequins reeled off a fourth successive Premiership victory after halting Bath's recent resurgence by winning 19-13 at The Rec.
England's Marcus Smith will not play again this year after suffering an ankle injury during the autumn finale against South Africa.
Joe Launchbury has signed for Harlequins on a multi-year deal and will join the Gallagher Premiership club in the summer following a stint in Japan.
Recap Saturday's Premiership action as Harlequins beat London Irish late in a fiery derby, while Northampton were too strong for Bristol.
Marcus Smith proved the difference for Harlequins as they put an end to Sale's unbeaten start in the Premiership this season.
Leicester's Tommy Reffell issued a timely reminder to Wales coach Wayne Pivac by scoring twice in his side's 27-19 win over Harlequins.
Premiership Rugby wants to introduce an independent regulator to oversee clubs' finances.
Worcester Warriors' matches against Gloucester and Harlequins have been cancelled as four players head to Bath on loan.
Harlequins survived a late scare to beat Northampton 35-29 in a Gallagher Premiership game that featured nine tries.
Exeter snatched a second successive home win with the last play of the game to thwart Harlequins' stunning second-half comeback.
Here's what happened on the opening day of the Gallagher Premiership season.
Recap Saturday's Premiership action as Saracens came from behind to beat a Quins side missing Marcus Smith; Leicester, Sale and Bristol also won.
Premiership Rugby has taken its first step towards "greater transparency" by publishing a salary cap report for the 2020-21 season.
Danny Care could still be in the reckoning to be part of England's 2023 Rugby World Cup squad following his recall.
Danny Care has been recalled to Eddie Jones' England squad for the first time in almost four years.
Saracens completed an immediate return to the Gallagher Premiership final after showing their steel to withstand a late Harlequins onslaught in a 34-17 victory.
Leicester Tigers have become the first Premiership club to go through a season on top of the table after every round, as the semi-finals are decided in Round 26.
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