La Rochelle broke Ulster hearts in the very final play to book a last-16 spot, while Ospreys, Saracens, Sharks and Bulls won too.
Leicester Tigers claimed a second Champions Cup win from as many rounds, beating Clermont, while Saracens dug deep to win at Lyon.
Lyon won their first major honour for 89 years as they claimed a thoroughly deserved 30-12 Challenge Cup final victory over Toulon.
Wasps bowed out of the European Challenge Cup at the semi-final stage as they were beaten 20-18 by a powerful Lyon side at the Matmut Stadium.
Karim Benzema's last-gasp winner sealed Real Madrid's stunning comeback as they recovered from 2-0 down to beat Sevilla 3-2.
Newcastle are extremely close to completing a £40m move for Bruno Guimaraes.
A round-up of Friday evening's three Challenge Cup matches, which saw Gloucester, Lyon and Toulon seal victories.
A round-up of all the action from Friday's opening two matches of this season's European Challenge Cup.