Gennaro Gattuso recorded his first win as AC Milan head coach with a 2-1 Serie A victory at home to Bologna.
Benevento claimed their first Serie A point in dramatic style as goalkeeper Alberto Brignoli scored an injury-time equaliser against AC Milan.
Ivan Perisic scored a hat-trick as Inter moved top of the table with a 5-0 win over Chievo.
Massimiliano Allegri's decision to rest two key players backfired as Juventus lost 3-2 at Sampdoria.
Second-half goals from Gonzalo Higuain and Juan Cuadrado meant Juventus came from behind to inflict a 12th straight Serie A defeat on struggling Benevento.
Unbeaten Napoli moved three points clear at the top of Serie A with a 3-1 win against Sassuolo at Stadio San Paolo.
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