Groningen moved up to ninth in the Eredivisie standings with a 2-0 home victory over struggling Roda JC on Friday.
Nicolai Jorgensen netted a brace as Eredivisie leaders Feyenoord thrashed city rivals Sparta Rotterdam 6-1 at De Kuip.
PSV had to settle for a point in their bid to close the gap on top two Feyenoord and Ajax after being held to a goalless draw at Roda JC.
A goal late in each half steered Heracles Almelo to three points as they beat NEC Nijmegen 2-0 at the Polman Stadion.
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Feyenoord remain top of the Eredivisie after Michiel Kramer's injury-time strike sealed a 3-3 draw with FC Utrecht
PSV Eindhoven closed on the Eredivisie leaders with a 3-1 win over ADO Den Haag at Philips Stadion.
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Ajax thumped NEC Nijmegen 5-0 as they tightened their grip on second place in the Eredivisie on Sunday.
PSV Eindhoven remain third after only drawing 0-0 at Willem II on Saturday, while Excelsior, Heracles and Groningen all won.
Go Ahead Eagles ended Feyenoord's 23-game unbeaten streak in the Eredivisie after a famous 1-0 victory at De Adelaarshorst.
PSV Eindhoven extended their unbeaten Eredivisie run to six games but were held to a 1-1 draw against FC Twente.
Feyenoord's lead at the top of the Eredivisie was cut to three points after a 2-2 draw at home to Heerenveen on Sunday.
Hakim Ziyech's strike was enough as Ajax edged Excelsior with a 1-0 win to keep the pressure on Eredivisie leaders Feyenoord.
Feyenoord dropped points in the Eredivisie for the first time this season after a 1-1 draw with rivals Ajax.
PSV Eindhoven closed the gap on second-placed Ajax to just a point with a 1-0 win over Sparta Rotterdam at Philips Stadion.
Feyenoord grabbed a late winner to secure their perfect record and Ajax's winning run continued.
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Heerenveen moved up to third in the Eredivisie after a 3-0 win over nine-man FC Groningen.