A first-half brace by debutant Tommy O'Brien helped Ireland register an impressive 34-5 victory over Georgia in Tbilisi.
New Zealand ran in seven tries to trounce Fiji 47-5, Australia overcame Georgia 40-29, while South Africa beat Portugal 64-21.
Winger Louis Rees-Zammit scored a hat-trick of tries as Wales beat Georgia 43-19 to secure first place in World Cup Pool C.
Fiji fought back from a half-time deficit to edge closer to a place in the Rugby World Cup quarter-finals
Italy face the first of two tough Rugby World Cup chances, Fiji look to clinch a first quarter-final since 2007 and South Africa seek a response.
Eddie Jones' Australia got their World Cup campaign off to a winning start, but remain in need of improvement after a 35-15 win over minnows Georgia.
Duhan van der Merwe led the charge with a double as five-try Scotland overcame another half-time deficit beat Georgia 33-6 at Murrayfield.
All the squads ahead of the 2023 Rugby World Cup in France, which runs from September 8 to October 28.
Georgia pick up a historic Test victory over Wales at the Principality Stadium in Cardiff, as Luka Matkava kicked the winning penalty.
Uncapped Scarlets back-row Josh Macleod has been named to start as one of six Wales changes to face Georgia on Saturday.
Wales have announced they will play autumn internationals against the southern hemisphere trio of Argentina, Australia and New Zealand.
France geared up for next weekend's much-awaited clash with New Zealand by labouring to a 41-15 victory over Georgia in Bordeaux on Sunday.
Georgia rugby coach Levan Maisashvili is in hospital after suffering "serious lung damage" from Covid-19 during the team's tour of South Africa.
Scotland's Test against Georgia in Tbilisi on July 17 has been cancelled after the hosts reported six positive Covid-19 cases in camp while in South Africa this week.
The Springboks management have suspended training and placed the squad in isolation after a positive Covid-19 result within their ranks.
Georgia are hoping to grow from their two-Test series against South Africa, who are warming up for the British and Irish Lions.
Sky Sports will show the Springboks' two warm-up Tests against Georgia ahead of the British & Irish Lions tour of South Africa.
Fiji wing Nemani Nadolo marked his return to Test rugby with a hat-trick as they secured an emphatic 38-24 Nations Cup victory over Georgia.
Rugby-isolation at an end as Fiji get COVID-19 all-clear as they prepare to take on Georgia in the Autumn Nations Cup.
A lacklustre Ireland beat Georgia 23-10 on Sunday to wrap up the pool stages of the Autumn Nations Cup.
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