Harlequins produced a 47-19 win over Ulster that keeps them in the chase for home advantage in the Champions Cup knockouts, and leaves Ulster out.
Rounding up a busy Saturday with eight matches in the Champions Cup as Harlequins thump Cardiff and Exeter progress, but Sale and Bristol lose.
Harlequins moved to the top of the Premiership with a bonus-point win over Newcastle, while Bristol ended Sales' long winning home run.
Harlequins prop Joe Marler's arm injury is being assessed by specialists amid front-row concerns for England ahead of the Six Nations.
Northampton mounted a stunning fightback to beat Sale 21-17 and moved to the top of the Gallagher Premiership table with a sixth successive victory.
Bath top the Gallagher Premiership at Christmas after winning an absorbing battle with fellow title contenders Harlequins 25-17 at the Rec.
Sale produced a superb second-half show to open their Champions Cup campaign with a 28-5 victory over Stade Francais at AJ Bell Stadium.
Marcus Smith said it was "quite scary" to see England team-mate Owen Farrell step away from international rugby.
Marcus Smith won the duel between England's fly-halves in waiting but it was the contribution of Harlequins' pack that underpinned a 36-3 win over Sale.
Saracens dealt with the early loss of three key players to make it four wins in a row as they rain in six tries during a thumping 38-10 victory over Harlequins.
A round-up of Saturday's Premiership action as Harlequins go top of the table with win at Leicester, while Sale prevail again away to Bristol.
Jamie Shillcock returned to haunt former side Bath as he scored the winning penalty with the last kick of the game to snatch Leicester a 25-24 Gallagher Premiership win.
Harlequins picked up their first league win of the Premiership season with a hard-fought 22-14 victory over Exeter at the Stoop.
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Zach Mercer, Danny Care and Val Rapava-Ruskin are included in England's initial 28-player Rugby World Cup training squad.
A round-up of Saturday's Gallagher Premiership action as London Irish finished a difficult week on a high.
Sale Sharks booked a home tie in the Gallagher Premiership play-offs after digging deep to defeat Gloucester 25-22 at Kingsholm as part of Saturday's action.
A round-up of all of the action from Saturday's three other Heineken Champions Cup round of 16 games.
A round-up of Sunday's Gallagher Premiership action as Saracens beat Harlequins and Leicester Tigers beat Bristol Bears, while London Irish beat Northampton Saints.
A round-up of Sunday's Gallagher Premiership action as Leicester Tigers won at Gloucester and London Irish beat Sale Sharks, while Bristol Bears thumped Harlequins.
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