Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.
Barcelona begin their Copa del Rey defence against Hercules, while Real face a trip to Leon to take on Cultural y Deportiva Leonesa.
Athletic Bilbao defender Aymeric Laporte says he has no regrets over rejecting a move to Manchester City in the summer.
Goals from Antoine Griezmann and Kevin Gameiro helped Atletico Madrid to a 2-0 win at Valencia on Sunday.
Three-time champions Inter Milan face a battle to get through Europa League Group K after a second successive defeat.
Athletic Bilbao ended Sevilla's unbeaten start in La Liga with a 3-1 victory at San Mames, while Eibar beat Real Sociedad 2-0.
Guillem Balague talks about Valencia's problems and potential candidates for the top job at the Mestalla, plus more.
Las Palmas' impressive start to the campaign hit the skids in San Sebastian as they were torn apart 4-1 by Real Sociedad.
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Red Bull Street Style World Final
8th November 2016