Sevilla climbed into the top half of the La Liga table after beating nine-man Valencia 1-0 on Sunday.
Former Manchester United striker Bebe has suggested his game has similarities with that of Cristiano Ronaldo.
Valencia hit five to beat high-flying Celta Vigo, while Eibar continued their rise up La Liga with victory over Getafe.
Eibar maintained their top-six La Liga position after an own goal gave them a 1-0 victory over Rayo Vallecano.
Neymar netted four goals as Barcelona overcame Rayo Vallecano 5-2 to join Real Madrid at the top of the standings.
Luis Suarez is fit for Barcelona after recovering from a muscle injury ahead of the clash with Rayo Vallecano.
Barcelona and Real Madrid will start their Copa del Rey campaigns against third-tier clubs.
Former Manchester United striker Bebe has refused to rule out a return to Old Trafford.
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