Serie A champions Juventus saw their 47-match unbeaten home league record come to an end against Udinese.
Defending champions Juventus suffered a shock 1-0 home defeat to Udinese in their Serie A opener on Sunday.
Striker Matej Vydra is back with Watford, this time on a permanent basis after signing a five-year deal to join the club from Udinese.
Juventus have exercised the option to buy Argentine Roberto Pereyra from Udinese, the Serie A champions have announced.
Andrea Stramaccioni will step down as Udinese head coach after just one year when his contract expires at the end of the June.
Cagliari drew a line under 11 years in Serie A by beating Udinese 4-3 in their last game before submitting to relegation.