Valencia won in La Liga for the first time since October, beating Espanyol 2-1 at the Mestalla.
Athletic Bilbao were held to a goalless draw by neighbouring Alaves on Sunday while Real Betis beat Leganes 2-0.
Copa del Rey holders Barcelona have been drawn against Real Sociedad in the quarter-finals while Real Madrid take on Celta Vigo.
Can Barcelona keep up with Real Madrid? Will Iago Aspas' remarkable scoring streak continue? What to look out for in La Liga this weekend.
A review of Tuesday's action in the Copa del Rey, as Atletico Madrid claimed a first-leg lead against Las Palmas.
La Liga side Espanyol were dumped out of the Copa del Rey at the last-32 stage as second-tier Alcorcon forced a penalty shootout win.
Mikel San Jose's stoppage-time winner completed a late comeback for Athletic Bilbao who were 2-1 winners at home to 10-man Celta Vigo.
Manchester United will face Saint-Etienne in the Europa League round of 32, while Spurs will take on Gent.
Dundalk's hopes of qualifying for the Europa League knockout stages were ended after a 2-1 defeat at Maccabi Tel-Aviv.
Pablo Fornals' injury-time equaliser kept the relegation heat on Valencia as Malaga rescued a 2-2 draw at the Mestalla.
Barcelona were held 1-1 by lowly Hercules in their Copa del Rey last 32, first-leg match while Atletico won 6-0 at Guijuelo.
Can Barcelona keep pace with Real Madrid in the La Liga title race? Sky Bet provide their tips for this weekend's action...
Inter Milan let a two-goal lead slip as they crashed out of the Europa League with a 3-2 defeat to Hapoel Be'er Sheva.
Sevilla came from 2-0 down to beat Deportivo La Coruna 3-2 at the Estadio Riazor, while Eibar won 1-0 at home to Celta Vigo.
Man City's Nolito says he would one day like to return to Celta Vigo and admits he has experienced loneliness in England.
Villarreal moved up into third place in La Liga with a 2-0 win over Real Betis to increase the pressure on Gus Poyet.
We look ahead to another eye-catching round of fixtures in La Liga, including champions Barcelona's trip to Sevilla.
Aritz Aduriz netted five goals in Athletic Bilbao's 5-3 win over Genk in the Europa League on Thursday, as Ajax, Schalke, Shakhtar and Zenit all progressed.
Iago Aspas scored twice as Celta Vigo beat Deportivo La Coruna 4-1 in a Galician derby in La Liga on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.