Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Roma closed the gap to Serie A leaders Juventus to a point after a thrilling 5-3 win at Chievo.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Juventus' Gonzalo Higuain failed to score on his long-awaited return to Napoli as the game ended 1-1, while Crotone beat Chievo.