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Daniele De Rossi a 'major doubt' for Italy's clash with Germany

Italy's midfielder Daniele De Rossi reacts during Euro 2016 round of 16 football match between Italy and Spain at the Stade de France stadium in Saint-Deni

Daniele De Rossi is a major doubt for Italy's Euro 2016 quarter-final clash with world champions Germany on Saturday, according to the Azzurri's medical staff.

De Rossi has been crucial for Antonio Conte's side as they upset pre-tournament predictions to top Group E and then swept aside defending champions Spain on Monday to set up a last-eight clash in Bordeaux.

But as he continues to suffer from a "serious right thigh injury" picked up in the 2-0 win over Spain at the Stade de France, Azzurri team doctor Enrico Castellacci admitted the Roma midfielder is unlikely to return in time.

"It's a very serious situation," said Castellacci. "We're trying everything to get him back in time. But we can't give any prognosis."

The loss of De Rossi is a significant blow for Italy as they look to knock Germany out for the second Euros in succession, having beaten them 2-1 in the Euro 2012 semi-final in Warsaw.

Their situation is not helped by the ongoing absence of Lazio winger Antonio Candreva.

Candreva, one of Italy's top players in their impressive opening win over Belgium, suffered a hamstring injury in their second group game, a 1-0 win over Sweden.

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Italy winger Antonio Candreva
Image: Antonio Candreva was injured in Italy's match against Sweden

Castellacci admitted the player has been "working really hard" in a bid to win his fitness battle but admitted: "He's made clear progress, but not enough to warrant his immediate return to the team.

"He's getting better, but he's not cured yet."

The absence of suspended midfielder Thiago Motta is a further headache for Conte as Italy look to extend their eight-match unbeaten record against Germany in major tournaments.

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