Inter Milan returned to the top of Serie A with a comfortable 4-0 home win over Frosinone on Sunday evening.
Riccardo Saponara scored the only goal of the game as Empoli recorded a 1-0 win in Palermo on Monday night.
Gonzalo Higuain's goal saw Napoli beat Serie A leaders Fiorentina 2-1, while Lazio were beaten 2-1 by Sassuolo.
Fiorentina ended Inter Milan's perfect record in stunning style while AC Milan were beaten and Lazio moved up to fourth.
Juventus could only draw 1-1 at home to Frosinone in Serie A on Wednesday, as leaders Inter Milan beat Hellas Verona 1-0.
A Gonzalo Higuain-inspired Napoli ran riot against Lazio while there were also wins for Inter Milan and Fiorentina.