Alvaro Morata stepped off the bench to to extend Spain's unbeaten run under Julen Lopetegui, salvaging a 2-2 draw against Colombia.
Alexis Sanchez played a starring role as Chile beat Venezeula 3-1 on Tuesday to boost their World Cup qualification hopes.
From Argentina to Australia, read our World Cup qualifying update ahead of this week's internationals...
Uruguay were denied an impressive win in Colombia as Yerry Mina's 84th-minute strike earned a 2-2 draw.
Wales and England have both risen in the latest FIFA rankings after wins in their World Cup qualifiers earlier this month.
Neymar's second-half strike earned Brazil a 2-1 victory in their World Cup South American qualifying clash with Colombia.