Gaston Pereiro was PSV Eindhoven hero as he scored twice in a 2-1 win against previously-unbeaten Eredivisie leaders Ajax.
Feyenoord moved up to second in the Eredivisie with a 2-0 victory over PEC Zwolle while FC Twente ended their winless start.
Heracles Almelo moved to the top of the Dutch league with a 2-1 win over champions PSV Eindhoven at the Polman Stadion on Saturday.
There were wins for Ajax and Feyenoord in the Eredivisie on Sunday, while FC Twente slipped to defeat.
Michael de Leeuw rescued a point for Groningen in a 1-1 draw with Twente in the Eredivisie on Wednesday, as NEC beat Excelsior 1-0.
Dutch club FC Twente have signed teenage striker Thomas Agyepong from Manchester City on loan.