Davy Klaassen scored twice as Ajax Amsterdam trounced SC Cambuur 5-1 to extend their lead at the top of the Eredivisie.
Eredivisie leaders Ajax hammered Roda JC 6-0 to open up a three-point gap at the top of the table.
PSV Eindhoven and Heracles maintained their pressure on the Eredivisie's top two with late away wins on Saturday.
Alireza Jahanbakhsh was NEC Nijmegen's hero with a two-goal haul helping to beat Ajax, condemning Roda JC to the drop.
Ajax clinched their fourth successive Eredivisie title with a 1-1 draw against Heracles Almelo on Sunday.
Roda JC's place in the Eredivisie's bottom three was confirmed on Saturday as they fell to a 3-0 defeat to FC Twente.