Serie A champions Juventus saw their 47-match unbeaten home league record come to an end against Udinese.
Simone Zaza struck twice as Sassuolo beat 10-man Genoa 3-1 on Sunday to finish their Serie A campaign on a high.
Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Sassuolo defeated 10-man Udinese 1-0 on Sunday afternoon to continue their strong finish to the season.
Domenico Berardi's hat-trick fired Sassuolo to a 3-2 victory over nine-man AC Milan on Sunday afternoon.