Las Palmas ended 10-man Villarreal's winning run thanks to Kevin Prince Boateng's strike in a 1-0 success.
Deportivo La Coruna triumphed 1-0 at Sporting Gijon on Sunday, as Las Palmas and Athletic Bilbao also claimed La Liga wins.
Barcelona and Real Madrid are both strong home favourites to build on crucial weekend victories in La Liga on Wednesday.
Relive the action from the Bernabeu as Real Madrid drew 3-3 with Las Palmas in La Liga.
Real Sociedad maintained their push for a top-four spot in La Liga with a 1-0 win at Las Palmas on Friday.
Atletico Madrid reclaimed fourth spot in La Liga with a dramatic late 3-2 win over Celta Vigo on Sunday night.
Revista De La Liga will return to Sky Sports screens this week, hosted by Spanish football expert Guillem Balague.
Deportivo La Coruna recorded their fifth straight draw after coming from a goal down to tie 1-1 at Las Palmas.
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