Inter Milan suffered a surprise 2-0 defeat to Chievo on the opening weekend of Serie A while Napoli also struggled.
Tottenham are interested in forward Franco Vazquez, according to Palermo president Maurizio Zamparini.
Francesco Totti made his 600th Serie A appearance as Roma moved up to second spot with a 3-0 win over Chievo.
Juventus celebrated winning the Serie A title for the fifth year in a row by beating relegation-threatened Carpi 2-0.
Juventus moved a step closer to a fifth straight Serie A title after pulling nine points clear with a 4-0 win over Palermo.
Davide Ballardini has taken over as the new coach of Serie A strugglers Palermo following the departure of Walter Novellino.