A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Juventus saw off Pescara 3-0 on Saturday to take a seven-point lead at the top, while Napoli and Chievo also claimed wins.
Roma were unable to keep pace with Serie A leaders Juventus after they were held to a goalless draw at struggling Empoli.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Arkadiusz Milik fired a second-half double as Napoli moved top of Serie A following a 3-1 home win against Bologna.
Fiorentina put five goals past relegated Pescara only to miss out on a Champions League spot.