Barcelona begin their Copa del Rey defence against Hercules, while Real face a trip to Leon to take on Cultural y Deportiva Leonesa.
Barcelona dismissed 10-man Sporting Gijon in La Liga on Saturday, with Neymar scoring twice in a 5-0 victory.
Relive the action as Barcelona beat Sporting Gijon 5-0 in La Liga on Saturday afternoon.
Las Palmas' impressive start to the campaign hit the skids in San Sebastian as they were torn apart 4-1 by Real Sociedad.
The 21st season of live Spanish football on Sky Sports gets underway this weekend with over 300 games available throughout the campaign.
Malaga have completed the signing of highly-rated winger Jony Rodriguez from La Liga rivals Sporting Gijon.
Jon Driscoll and Terry Gibson return for an in-depth take on all the action and major talking points in La Liga.
The number of Madrid teams in La Liga dropped from four to two as Getafe and Rayo Vallecano were relegated on the final day.
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