Nathan Ellington (pictured) was the hero again for The Latics, following his brace against Fulham in midweek, netting twice against The Hatters.
Ellington scored on 37 and 64 minutes to put the home side in the driving seat, whilst Michael Flynn settled the clash with a late third.
Cardiff City eased into the Third Round of the FA Cup as they cantered past Conference outfit Margate.
The Gate had previously despatched Division Three outfit Leyton Orient, but there was to be no repeat of the giant-killing as Lennie Lawrence's side proved too strong.
Peter Thorne opened the scoring after 28 minutes to set The Bluebirds on their way. The tie was then sealed less than ten minutes later when midfielder Willie Boland struck.
Leo Fortune West added a third two minutes from time as Margate collapsed.
Darlington booked their place in the Third Round draw with a comfortable 4-1 home win over conference side Stevenage.
Richard Hodgson had the home fans celebrating early on with a goal after two minutes, however Richard Howell equalised quickly after.
On-loan striker Richard Offiong restored Darlo's advantage with a goal before the break, and the tie was settled in the second half following goals from Barry Conlon and a second from Offiong.
10-man Brentford booked their place in the next round of the competition with a hard-fought 2-1 win over York City.
The Bees were down to ten-men after 30 minutes when Andrew Frampton was sent-off for violent conduct. However, the handicap inspired the team to take the lead a few minutes later through Mark McCammon.
Lee Bullock equalised for The Minstermen just after the hour mark, before midfielder Stephen Hunt won the tie for the South West London outfit in the last minute.
Morecambe ensured they would be in the hat for a money-spinning Third Round tie following a sea-saw battle with Chester City.
Phil Bolland had City ahead on 25 minutes, but Jim Bentley equalised virtually straight after.
Former Boston United striker Daryl Clare restored the visitors lead with a goal before the break, however their joy was hindered by Ryan Sugden's dismissal moments later.
There was still time for Bentley for equalise before the end of the half, before Adriano Rigoglioso put Morecame ahead with a low strike from 10-yards out after 57 minutes.
Shrewsbury make no mistake against Barrow at Gay Meadow seeing off the non-league side 3-1.
Former West Brom man Jason van Blerk put The Shrews ahead and Nigel Jemson made it 2-0 on 19 munutes.
Steve Housham give the visiting faithful hope of earning a replay when he pulled a goal back on the hour mark, before Jemson netted his second and settled the clash late on.
Plymouth coasted past Stockport County with a 3-0 win at Edgeley Park thanks to two early goals.
Ian Stonebridge and David Friio had the visitors in command with early goals, before captain Paul Wotton completed the win with a late third.
Southport advanced in the cup thanks to two first half goals against Farnborough Town. Lenny Piper and Danny Carroll were the heroes for Southport.
Town completed their impressive win when Dean Green scored late on much to the delight of the travelling faithful.
Crewe inflicted more agony on struggling Mansfield Town after knocking The Stags out of the cup. Ben Rix and a second half spot-kick from Dave Brammer settled the tie.
Dean Ashton continued his excellent cup-scoring record with a late third on 78 minutes to finish off the out-of-form Stags.
Bournemouth earned a replay at Roots Hall against Southend United after Mark Rawle equalised Karl Broadhurst's effort, whilst Carlisle United drew 0-0 against Scunthorpe United.
Cheltenham Town surprised high-flying Oldham with a 2-1 win at Boundary Park. Two goals in the space of three minutes from Mark Yates and Paul Brayson earned The Robbins the victory.
Will Haining pulled a goal back late on, to give the home fans hope, but it proved nothing more than a consolation.
A late Bradley Allen goal earned Bristol Rovers a replay against Rochdale, after Clive Platt's early strike looked to have sealed Dale's passage.
Meanwhile, Blackpool and Exeter City booked their place in the Third Round with 3-1 home wins over Torquay United and Rushden and Diamonds respectively.
Martin Gritton fired The Gulls ahead on 8 minutes, his sixth in seven games, however an own goal from Reuben Hazell levelled matters shortly after.
Scott Taylor and John Murphy ensured a shock stayed off the cards with second half goals for the Seasiders, and it turned ugly in injury time when Alex Russell and David Graham were both sent-off.
Barry McConnell and Justin Walker put City two-up on the hour mark, although Onandi Lowe gave Diamonds hope with a goal back.
However, their resistance was finally broken when Renier Moor settled the tie with a third on 85 minutes.
Cambridge United had a foot in the door of the next round after Adam Tann fired the home side into a 2-0 lead at the Abbey, however second half goals from Darryn Stamps and Chris Hargreaves rescued a reply for Town.
Dagenham & Redbridge ensured their name would be in the hat for the next round after a hard-fought 2-1 win over fellow non-leaguers Crawley Town.
Nic McDonnell had the home fans in raptures early doors, however Junior McDougald levelled matter on 26 minutes.
Things turned sour for Town late on when Ellis Hooper was dismissed for receiving his second yellow card, before Mark Janney nicked the win in the last minute.
Macclesfield Town ended Vauxhall Motors' dreams of making the third round after two late goals by Kyle Lightbourne and Matthew Tipton sent The Silkmen through.
The Bermudan striker got what proved to be the winner with eight minutes to go after Tipton played in a low cross for the tall striker to slot the ball past Vauxhall goalkeeper Andy Ralph.
Tipton would seal victory for David Moss' squad as his run and shot made it 2-0 in injury time to the Division Three side.
Alvin McDonald's men were unable to hold out for what was looking to be a 0-0 draw and a home replay for the Unibond League Premier Division side but it was not to be in the end at Moss Rose.
Click here for FA Cup match summaries:
Blackpool 3 Torquay United 1
Bristol Rovers 1 Rochdale 1
Cambridge United 2 Northampton Town 2
Crawley 1 Dagenham & Redbridge 2
Crewe Alexandra 3 Mansfield Town 0
Exeter City 3 Rushden & Diamonds 1
Darlington 4 Stevenage Borough 1
Macclesfield Town 2 Vauxhall Motors 0
Margate 0 Cardiff City 3
Morecambe 3 Chester City 2
Oldham Athletic 1 Cheltenham Town 2
Scunthorpe United 0 Carlisle United 0
Shrewsbury Town 3 Barrow 1
Southend United 1 Bournemouth 1
Southport 0 Farnborough Town 3
Stockport County 0 Plymouth Argyle 3
Wigan Athletic 3 Luton Town 0
York City 1 Brentford 2
