Leaders Yeovil suffered a shock 2-1 defeat at Grimsby Town.
Yeovil missed the chance to extend their lead at the top of the table after going down 2-1 at Grimsby.
Andy Parkinson's late goal (87) gave Grimsby the points after Michael Reddy had cancelled out Arron Davies' early opener for Yeovil.
Swansea boosted their promotion hopes with a 2-1 win over Scunthorpe.
Lee Trundle gave the hosts the lead on 25 minutes, but the lead was short-lived as Andy Butler levelled matters after 33 minutes.
Trundle grabbed the winner for Swansea on the hour mark when converting from the penalty spot.
Macclesfield moved level on points with Swansea and Scunthorpe after a 2-1 win over Bristol Rovers.
Jon Parkin was the hero for Macclesfield with both goals (45, 62) with Steve Elliott scoring for Rovers.
Southend remain in touch with the leading pack after a 1-0 win over Bury at Roots Hall.
Freddy Eastwood grabbed the all-important winning goal for The Shrimpers on 42 minutes.
Cheltenham gave their promotion hopes a lift with a 1-0 victory over fellow promotion hopefuls Lincoln City.
Stephen Guinan netted the only goal of the game on 63 minutes for Cheltenham.
Cambridge climbed off the bottom of the table with a last-gasp 2-1 win over Oxford.
Shane Tudor popped up with the winner in the final minute after John Turner (69) had cancelled out Steve Basham's opener for Oxford.
Northampton moved into the play-off places with a narrow 1-0 victory at Boston.
Martin Smith scored the all-important winning goal 17 minutes from time.
Leyton Orient dealt Darlington's promotion hopes a blow with a 1-0 win at Brisbane Road thanks to Lee Steele's 26th minute goal.
Kidderminster slumped to the bottom of the table after a 1-1 draw at Rochdale.
Chris Beardsley gave the strugglers the lead on 18 minutes, but Ricky Lambert's 40th minute strike earned Rochdale a point.
Notts County climbed further away from trouble with an impressive 2-1 success at Wycombe.
Kelvin Wilson fired County in front on 13 minutes only for Ian Stonebridge to level matters seconds later.
Stefan Oakes netted the winner for County on 71 minutes.
Shrewsbury were the biggest winners of the day with a thumping 5-0 victory over Chester.
Jamie Tolley broke the deadlock on 28 minutes and Luke Rodgers added a second two minutes before the break.
Jake Sedgemore made it 3-0 from the penalty spot on 57 minutes after George Elokobi was sent off for a professional foul.
Ryan Lowe and Kelvin Langmead completed the rout for Shrewsbury.
Rushden & Diamonds picked up a valuable point with a goalless draw at home to Mansfield.
Click below for match summaries:
Boston United 0-1 Northampton Town
Cambridge United 2-1 Oxford United
Cheltenham Town 1-0 Lincoln City
Grimsby Town 2-1 Yeovil Town
Leyton Orient 1-0 Darlington
Macclesfield Town 2-1 Bristol Rovers
Rochdale 1-1 Kidderminster Harriers
Rushden & Diamonds 0-0 Mansfield Town
Shrewsbury Town 5-0 Chester City
Southend United 1-0 Bury
Swansea City 2-1 Scunthorpe United
Wycombe Wanderers 1-2 Notts County
Click here for the League Two table.
