Internazionale beat Siena 2-0 at home, while Roma came from behind to beat Atalanta 2-1.
Internazionale stretched their unbeaten start to the season to 14 games with a comfortable 2-0 win over Siena.
The current Serie A leaders have failed to win on just three occasions this term and scored a goal in each half against Siena.
Argentine full-back Nicolas Burdisso handed Inter the ideal start when scoring after just 11 minutes.
And Burdisso's compatriot Hernan Crespo made the game safe by adding the second goal of the match on 54 minutes.
Roma remain four points behind Inter in second after a brace of Francesco Totti penalties clinched a 2-1 win at home to Atalanta.
The away side took the lead on 20 minutes through Riccardo Zampagna before Totti converted the first of his spot-kicks on 50 minutes.
Totti struck again from 12 yards on 63 minutes to hand Roma the points as Atalanta finished the game with 10 men after Massimo Donati was sent off a minute from time.
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