Chelsea will face Atletico Madrid in the Champions League last 16, while Liverpool play last season's semi-finalists RB Leipzig.
Romelu Lukaku kept Inter Milan's hopes of reaching the Champions League last 16 alive, with Real Madrid and Atletico Madrid facing nervous final matchdays.
Robert Lewandowski continued his hot goal-scoring streak with a hat-trick in Bayern Munich's 5-0 thumping of Eintracht Frankfurt.
Zlatan Ibrahimovic made a winning return to the AC Milan team as his quickfire double won the Milan derby, while Real Madrid and Barcelona suffered shock defeats.
Leicester are in talks with Atalanta over signing full-back Timothy Castagne.