Real Madrid reached the Copa del Rey quarter-finals despite a 1-0 defeat to Leganes in the second leg of their last-16 tie on Wednesday.
Isco's third start under Santiago Solari ended in disappointment as Real Madrid were beaten by Leganes in the Copa del Rey.
Real Madrid steadied the ship as a 3-0 win over Leganes put them on the brink of the Copa del Rey quarter-finals.
A late header from Wissam Ben Yedder ensured 10-man Sevilla escaped with a point at Leganes in La Liga on Sunday.
Leganes survived a late Celta Vigo onslaught to earn a point in a goalless LaLiga draw.
Iago Aspas scored twice as Celta Vigo got back on track in La Liga with a 2-0 victory over Huesca.
Alaves missed the chance to jump to the top of the La Liga table, falling to a surprise 1-0 loss at struggling Leganes.
Diego Godin battled through injury to score a dramatic late winner as Atletico Madrid beat Athletic Bilbao 3-2 in La Liga on Saturday.
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