Ousmane Dembele and Lionel Messi fired Barcelona to a confidence-boosting 2-0 win at in-form Sevilla on Saturday to keep the pressure on Atletico Madrid.
Real Madrid continued to cling to the coat-tails of city rivals Atletico in the La Liga title race after winning 2-0 at home against Valencia.
Real Madrid suffered a shock 2-1 defeat to third division Alcoyano to exit the Copa del Rey after extra-time on Wednesday night.
Real Madrid moved top of La Liga after a 2-0 home win over Celta Vigo with Lucas Vazquez and Marco Asensio on the scoresheet.
Lionel Messi equalled Pele's record of 643 goals for a single club after scoring for Barcelona against Valencia in La Liga on Saturday.
A costly mistake from goalkeeper Thibaut Courtois helped Alaves secure a 2-1 La Liga victory over Real Madrid at the Alfredo Di Stefano stadium.