Gabriel is set to replace the injured Shkodran Mustafi in the Arsenal defence as they travel to Everton on Tuesday evening.
Manager Arsene Wenger confirmed that the Germany international would be sidelined for around three weeks, and will miss much of the Christmas period.
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Alongside Gabriel, Rob Holding will also be included in the squad to provide cover with the Gunners boss assured they can step up to fill the gap.
"It is a challenge because we had good defensive stability. We have Gabriel [Paulista], we have [Rob] Holding who can come in for him. Overall, I am confident both can do well, but that's one of the tests we have," Wenger said.
Everton continue to struggle after a good start to the season, failing to win any of their last five Premier League games and suffered a 3-2 loss to Watford on Saturday.
But the Toffees remain in the top half of the table and could briefly jump into seventh place with a victory against the Gunners this week.
Aside from the defensive move around, Aaron Ramsey will also remain sidelined with a hamstring problem of his own.
Arsenal's longer-term injured stars are still not ready to return, including Santi Cazorla, Per Mertesacker and Danny Welbeck.
Everton have no new injuries ahead of Arsenal's visit, but could makes changes as they look to change their fortunes.
Manager Ronald Koeman has the option of recalling Ross Barkley, Aaron Lennon and Enner Valencia to the starting side while Yannick Bolasie and Mo Besic are the only first-team absentees with long-term knee ligament problems.
Everton's only win in their last 18 league games against Arsenal was their 3-0 victory in April 2014 (D6 L11).
Arsenal have won more Premier League games against Everton (29) than they have against any other side.
In fact, Everton have lost 93 times to Arsenal in the league, the most defeats by one club to another in English league history.
A win for the Gunners at Goodison Park would make it their 12th in the Premier League there - only at Villa Park (12) have they obtained as many away wins at a single ground.
Everton have conceded exactly two goals in each of their last four league games against Arsenal.
Olivier Giroud has scored five goals in his last six games against Everton in all competitions.
The Gunners haven't lost on a Tuesday in the Premier League since February 2006 v Liverpool (W10 D7).
Romelu Lukaku has scored (9) or assisted (3) 12 of Everton's last 15 Premier League goals.
Since the start of 2013-14, Lukaku has scored 52 of Everton's 187 Premier League goals (28%) and no other player has more than 20 goals for the club in this period.
Alexis Sanchez has had a hand in 26 goals in his last 26 Premier League appearances for Arsenal (18 goals, 8 assists).
Arsenal are Sky Bet's 10/11 favourites with Everton a 29/10 chance while the draw is priced at 10/11. The Gunners were installed as 4/1 second favourites for the title following the weekend action as they kept pace with leaders Chelsea while their three other main rivals dropped points.
Sanchez is the 7/2 favourite in the first goalscorer betting with Lukaku the hosts' main threat at 11/2 and 13/2 for another double.